Prof. Brendan Griffin

University College Cork, School of Pharmacy, Ireland

Lecturer in Pharmaceutics at the School of Pharmacy at University College Cork

Coordinator of the InPharma Project, Supervisor of ESR2, ESR3, ESR4, ESR7 and ESR13

Background

Brendan Griffin is currently Professor of Pharmaceutics and Head of School of Pharmacy at University College Cork. His research interests include formulation technology to improve oral drug delivery and computational pharmaceutics tools to streamline drug product development.  He has authored over 85 peer reviewed publications;  he is Project Coordinator of the €4m H2020 funded Marie Curie Innovative Training Network (ITN) (www.pearrl.eu) and recently was successfully in leading a new ‘InPharma’ ITN (www.inpharma-network.eu) to establish a new fully integrated, animal-free, end-to-end modelling approach in oral drug product development.

Selected Publications

  • Griffin, B. T.; Dressman, J. B. (2019) ‘The PEARRL reviews – innovative drug development strategies tailored to facilitate earlier access to new oral medicines’. Journal of Pharmacy and Pharmacology, 71 (4):439-440. https://doi.org/10.1111/jphp.13083 
  • Bennett-Lenane, H., Koehl, N.J., O’Dwyer, P.J., Box, K, O’Shea, J.P., Griffin, B.T. (2021). Applying Computational Predictions of Biorelevant Solubility Ratio Upon Self-Emulsifying Lipid-Based Formulations Dispersion to Predict Dose Number, Journal of Pharmaceutical Sciences, https://doi.org/10.1016/j.xphs.2020.10.055
  • Cussotto, S., Walsh, J., Golubeva, A.V., Zhdanov, A.V., Strain, C.R., Fouhy, F., Stanton, C.f, Dinan, T.G., Hyland, N.P., Clarke, G., Cryan, J.F., Griffin, B.T. (2021) ‘The gut microbiome influences the bioavailability of olanzapine in rats’. EBioMedicine (published by THE LANCET),  66:103307. https://doi.org/10.1016/j.ebiom.2021.103307   
  • O’Callaghan, J., Barry, S.P., Bermingham, M., Morris, J.M., Griffin, B.T. (2018) Regulation of biosimilar medicines and current perspectives on interchangeability and policy, V 75, Issue 1, pp 1–11 European Journal of Clinical Pharmacology,https://doi.org/10.1007/s00228-018-2542-1
  • Donovan MD, Abduljalil K, Cryan JF, Boylan GB, Griffin BT. (2018) ‘Application of a Physiologically-Based Pharmacokinetic Model for the Prediction of Bumetanide Plasma and Brain Concentrations in the Neonate’. Biopharmaceutics & Drug Disposition, http://dx.doi.org/10.1002/bdd.2119
  • Enright, E.F., Gahan, C.G.M., Joyce, S.A, Griffin, B.T., (2017) ‘Impact of gut microbiota-mediated bile acid metabolism on the solubilization capacity of bile salt micelles and drug solubility’. Molecular Pharmaceutics, 133 :170-186. https://doi.org/10.1021/acs.molpharmaceut.6b01155
  • B.T. Griffin, M. Kuentz, M. Vertzoni, E.S. Kostewicz, Y. Fei, W. Faisal, C. Stillhart, C.M. O’Driscoll, C. Reppas, J.B. Dressman, (2014) Comparison of in vitro tests at various levels of complexity for the prediction of in vivo performance of lipid-based formulations: Case studies with fenofibrate, 86  427-437. European Journal of Pharmaceutics and Biopharmaceutics, https://doi.org/10.1016/j.ejpb.2013.10.016