This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 955756.

Dr. Jef Stappaerts

Janssen Pharmaceutica NV, Drug Product Development (Janssen), Belgium

Senior Scientist Biopharmaceutics at Janssen Pharmaceutica NV

Supervisor of ESR13


Jef Stappaerts is a senior scientist at Janssen Pharmaceutica NV (Janssen), which is the pharmaceutical branch of Johnson & Johnson. He graduated as a pharmacist at the KU Leuven in 2010 and received his PhD from the same university in 2014. After working as a post-doctoral researcher on a project focusing on drug-cyclodextrin aggregation, Jef started working as a biopharmaceutics expert at Janssen in 2017. In his current role, he provides end-to-end biopharmaceutics support to the early and late development portfolio using a combination of in silico and in vitro techniques. He is also involved in the Marie Curie Innovative Training Network (ITN) AgePOP consortium.

Selected Publications

  • Stappaerts J., Geboers S., Snoeys J., Brouwers J., Tack J., Annaert P., & Augustijns P. (2015) ‘Rapid conversion of the ester prodrug abiraterone acetate results in intestinal supersaturation and enhanced absorption of abiraterone: in vitro, rat in situ and human in vivo studies’. European Journal of Pharmaceutics and Biopharmaceutics, 90, 1-7,
  • Vinarov Z., Abdallah M., Agundez J., Allegaert K., Basit A.W., Braeckmans M., Ceulemans J., Corsetti M., Griffin B.T., Grimm M., Keszthelyi D., Koziolek M., Madla C.M., Matthys C., McCoubrey L.E., Mitra A., Reppas C., Stappaerts J., Steenackers N., Trevaskis N.L., Vanuytsel T., Vertzoni M., Weitschies W., Wilson C., Augustijns P. (2021). ‘Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review’. European Journal of Pharmaceutical Sciences, Volume 162 (2021) 105812,
  • Ryzhakov A., Thi T.D., Stappaerts J., Bertoletti L., Kimpe K., Sá Couto A.R., Saokham P., Van den Mooter G., Augustijns P., Somsen G.W., Kurkov S., Inghelbrecht S., Arien A., Jimidar M.I., Schrijnemakers K., Loftsson T. (2016) ‘Self-Assembly of Cyclodextrins and Their Complexes in Aqueous Solutions’. Journal of Pharmaceutical Sciences, 105(9), 2556-2569.