Annual Meeting 2024
Odense, Denmark, 10 – 14 June 2024
Welcome
The EU-funded InPharma project is working towards making drug development more predictable and reducing animal testing in drug development by using a fully integrated, animal-free, end-to-end modelling approach to the formulation of drugs for oral administration.
InPharma is the first European Industrial Doctorate (EID) that aims at eliminating animals from the development of oral drug formulations by substituting them with computational and bio-predictive in vitro tools. InPharma will apply an ‘end-to-end’ model-based drug development approach, by linking data emerging from drug discovery into computational models that predict the optimal formulation design, which is then integrated into models that predict drug levels in simulated human clinical trials. This end-to-end model-based approach is essential to advance innovation and competitiveness of Pharmaceutical R&D in Europe, and at the same time support the European Commission’s goal of animal-free testing.
The pharmaceutical industry is still lacking personnel trained in novel computational and laboratory-based technologies for oral drug formulation. InPharma will bridge this qualification gap by training doctoral students (early-stage researchers, ESRs) in computational pharmaceutics, innovative lab-based predictive tools and physiologically based pharmacokinetic (PBPK) modelling. In total, 13 ESRs have been recruited to work on individual projects as part of the InPharma network supported by experts in the field of oral drug development.
The InPharma project brings together the complementary expertise of six multi-national pharmaceutical companies, five world-class academic research institutions and eight partner organisations to ensure the best research and training conditions for each individual to reach the overall project goals. The ESRs have the opportunity to start their research careers in a truly intersectoral environment and each ESR will experience life as a researcher at an innovative pharmaceutical company and at one of the leading research institutions in Europe. The local PhD programmes will be complemented by network-wide training events designed to prepare the ESRs to become highly successful researchers in the pharmaceutical industry.
We hope that this final meeting will be a rewarding experience for all those attending the meeting and a kick-start in a successful career for the ESRs.
Welcome to the InPharma Annual Meeting 2024,
InPharma Annual Meeting Organising Committee
Day 1, 10 June 2024: InPharma Annual Meeting
9:00
ESR training activity
Shark tank introduction and preparation
12:00
Lunch
13:30
ESR 1 – 3 Research Presentations
(Max 20 minutes per ESR with 10 minutes afterward for questions/feedback)
15:00
Coffee break and discussions
15:30
ESR 4 – 6 Research Presentations
(Max 20 minutes per ESR with 10 minutes afterward for questions/feedback)
17:30
End of Day
Day 2, 11 June 2024: InPharma Annual Meeting and Joint NordicPop & InPharma International Symposium
09:00
ESR 7 – 9 Research Presentations
(Max 20 minutes per ESR with 10 minutes afterward for questions/feedback)
10:30
Coffee break
14:00
ESR 10 – 13 Research Presentations
(Max 20 minutes per ESR with 10 minutes afterward for questions/feedback)
17:00
Lunch break
14:15
ESR shark tank and supervisors/board management meetings
Joint NordicPop & InPharma International Symposium
15:30
Conference opening session
- Annette Bauer-Brandl (SDU Odense)
Welcome note - Jukka Rantanen (Copenhagen)
Enabling manufacturing solutions for personalized medicinal products - Bente Steffansen (Leo Pharma)
Prediction of human fraction dose absorbed (Fabs) and maximal absorbed dose (MAD) of low permeability drug substances
16:35
Session title: Vaginal drug delivery; Chair: Natasa Skalko-Basnet (UiT Tromsø)
- Natasa Skalko-Basnet (Tromsø) Efficient vaginal drug delivery: more important than ever
- Aleksandra Teleki (Uppsala) Microneedle-enabled drug delivery device for local treatment of vaginal infections
- Short communication – To be selected from abstracts
17:45
InPharma & NordicPOP posters
Up to 15 poster pitch presentations of 2 minutes each
18:15
Welcome reception
Day 3, 12 June 2024: Joint NordicPop & InPharma International Symposium
8:00
Session title: From Modelling to Artificial Intelligence in drug development – Chair: tbd
- Per Larsson (Uppsala)
Computational studies of pharmaceutical dosage forms - Himanshu Khandelia (Odense)
Interaction of drugs and small molecules with membranes and proteins using large-scale molecular simulations - Grzegorz Garbacz (Physiolution)
AMP and software for PK simulations and modeling - Short communication – To be selected from abstracts
9:30
Coffee break
9:45
Session title: PBBM for oral drugs, and current status for ophthalmic drugs – Chair: tbd
- Guillaume Louit (Siemens)
Modeling of supersaturating formulations: influence of polymer and bile on precipitation - Eva Maria del Amo Páez (Kuopio)
Ocular pharmacokinetics: routes, barriers and emerging models - Short communication – To be selected from abstracts
10:55
Coffee break
11:15
Session title: Solid state & Oral enabling formulations – Chair: Annette Bauer-Brandl (SDU Odense)
- Nair Rodriguez-Hornedo (University of Michigan)
Prediction and Usefulness of Cocrystal Transition Points - Susan DePaul (Solvias)
The Importance of the Solid Form of the API for Formulation Development - Holger Grohganz (Copenhagen)
Co-amorphous systems – from idea to production - Short communication – To be selected from abstracts
13:10
Poster session and lunch
14:20
Session title: Dissolution & beyond – Chair: Martin Brandl (SDU Odense)
- James Polli (Univ. Maryland, Baltimore)
Application of dissolution-hollow fiber membrane (D-HFM) system to amorphous solid dispersion performance - Karl Box (pIon)
Solubility Limited Absorption and the Impact of Particle Drift on Oral Fraction Absorbed - Christos Reppas (NKUA)
In vitro evaluation of drug presence in the micellar phase of contents of upper small intestine: Rationale, Challenges, Opportunities - Short communication – To be selected from abstracts
16:15
Coffee break and posters
16:35
Session title: Green Pharmacy – Session chair: Jaakko Teppo (Helsinki)
- Jaakko Teppo (Helsinki)
Introduction to environmental sustainability in drug discovery and development - Anssi-Pekka Karttunen (Helsinki)
bBproducts from other industries as pharmaceutical excipients (to be confirmed) - Short communication – To be selected from abstracts
17:15
Session title: Emerging Talents in Pharma Sciences – Chair: tbd
- Ann Christin Jacobsen (Odense)
Designing solid oleogels for dosage form individualization using Design of Experiments - Astrid Subrizi (Kuopio)
Targeting ocular tissues with RNA aptamers
Day 4, 13 June 2024: Joint InPharma/NordicPOP Summer School
8:30-11:45
Introductory Lectures (20-30 minutes each)
- PBBM modelling GProms
- The BioGit System
- Microdialysis Sampling
- Dissolution/Permeation PermeaPad Microtiterplate
- Dissolution/Permeation PermeaLoop
- Lipolysis
- Diffusivity of drug molecules (UV-method)
- Diffusivity of drug molecules (DOSY-NMR method)
11:30
Lunch
Day 4 and Day 5, 13/14 June 2024: Joint InPharma/NordicPOP Summer School
June 13th Afternoon 12:15 to 18:30 (two sessions with 15 min break)
June 14th Morning 8:30 to 11:30 (one session)
- PBBM modelling GProms
- The BioGit System
- Microdialysis Sampling
- Dissolution/Permeation PermeaPad Microtiterplate
- Dissolution/Permeation PermeaLoop
- Lipolysis
- Diffusivity of drug molecules (UV-method)
- Diffusivity of drug molecules (DOSY-NMR method)
Day 5, 14 June 2024: Generic and Transferable skills training
13:00
ESRs Career Training
14:00
End of Meeting
Main contact
Prof. Annette Bauer-Brandl, University of Southern Denmark
Professor of Pharmaceutics