This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 955756.

Annual Meeting 2023

Athens, EL, 12 – 16 June 2023

Welcome

The EU-funded InPharma project is working towards making drug product development more predictable and reducing animal testing in drug product development by using a fully integrated, animal-free, end-to-end modelling approach to the formulation of drugs for oral administration.

InPharma is the first European Industrial Doctorate (EID) that aims at eliminating animals from the development of oral drug formulations by substituting them with computational and bio-predictive in vitro tools. InPharma will apply an ‘end-to-end’ model-based drug development approach, by linking data emerging from drug discovery into computational models that predict the optimal formulation design, which is then integrated into models that predict drug levels in simulated human clinical trials. This end-to-end model-based approach is essential to advance innovation and competitiveness of Pharmaceutical R&D in Europe, and at the same time support the European Commission’s goal of animal-free testing.

The pharmaceutical industry is still lacking personnel trained in novel computational and laboratory-based technologies for oral drug formulation. InPharma will bridge this qualification gap by training doctoral students (early-stage researchers, ESRs) in computational pharmaceutics, innovative lab-based predictive tools and physiologically based pharmacokinetic (PBPK) modelling. In total, 13 ESRs have been recruited to work on individual projects as part of the InPharma network supported by experts in the field of oral drug development.

The InPharma project brings together the complementary expertise of six multi-national pharmaceutical companies, five world-class academic research institutions and eight partner organisations to ensure the best research and training conditions for each individual to reach the overall project goals. The ESRs have the opportunity to start their research careers in a truly intersectoral environment and each ESR will experience life as a researcher at an innovative pharmaceutical company and at one of the leading research institutions in Europe. The local PhD programmes will be complemented by network-wide training events designed to prepare the ESRs to become highly successful researchers in the pharmaceutical industry.

Welcome to the InPharma Annual Meeting 2023,

 InPharma Annual Meeting Organising Committee

Day 1, 12 June 2023: ESR Training

Location: Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A.

9:45

Welcome Reception

10:00

Welcome Speech/Corporate Presentation

10:30

Site Tour – Uni 2

12:00

Lunch

13:00

Site Tour- Uni 1

14:30

Regulatory Challenges / Advanced Oral Drug Formulations

14:50

Coffee break and discussions

15:00

Collaborative Research /UPH advanced oral drug formulations-LLC’s

15:20

Continuous Manufacturing Project/PAT

15:40

Closing Address “Future of Pharma”

16:00

End of Day


Day 2, 13 June 2023: ESRs Presentations

Location: Argyriadis Lecture Room, National and Kapodistrian University of Athens

09:00

ESR 1 – 4 Research Presentations
(Max 20 minutes per ESR with 10 minutes afterward for questions/feedback)

13:00

Lunch break

14:00

ESR 5 – 8 Research Presentations
(Max 20 minutes per ESR with 10 minutes afterward for questions/feedback)

17:00

End of Day


Day 3, 14 June 2023: ESRs Presentations & Board Meetings

Location: Argyriadis Lecture Room, National and Kapodistrian University of Athens

09:00

ESR 9 – 13 Research Presentations
(Max 20 minutes per ESR with 10 minutes afterward for questions/feedback)

13:00

Lunch break

14:00

Parallel sessions

Location: Argyriadis Lecture Room, National and Kapodistrian University of Athens

  • Dos and Don’ts in Scientific publishing
    Martin Brandl

Location: Drakopoulos Lecture Room, National and Kapodistrian University of Athens

  • Advisory Board
  • Supervisory Board

 

17:00

ESRs social activity – Acropolis museum


Day 4, 15 June 2023: InPharma Open Symposium

Location: Argyriadis Lecture Room, National and Kapodistrian University of Athens

The theme for the InPharma Symposium is Enabling drug products for oral administration: design and evaluation. There will be seven distinct sessions, as outlined below.

09:15 – 10:00

Drug polymorphs and co-crystals in pharmaceutical development
Rolf Hilfiker

10:00 – 10:45

Lipid-based formulations in capsules: formulation design and characterization
Vincent Jannin

10:45 – 11:15

Getting oral formulations with cyclodextrins right– relevant characterization and biopharmaceutical considerations
Rene Holm

11:15 – 12:00

Session 2: Physiologically relevant absorption modelling

12:00 – 12:45

Possibilities and limitations in translating in vitro dissolution data to in vivo performance for a pediatric formulation using physiologically based biopharmaceutics modeling and virtual BE trials – an industry case study
Neil Parrott

12:45 – 14:00

Lunch

14:00 – 14:45

Absorption Modelling using the Simcyp ADAM Model: Enabling Formulations
David Turner

14:45 – 15:15

Coffee

15:15 – 16:00

Factors affecting extrapolation of drug exposure from adults to pediatric populations after oral administration of pediatric aqueous suspensions: focus on dosing conditions
Marina Statelova

16:00 – 16:45

Mechanistic prediction of the in vivo performance of low solubility drugs/incompletely absorbed drugs using GI-Sim
Sara Carlet


Day 5, 16 June 2023: Generic and Transferable skills training

9:00

ESRs Training

accelopment Schweiz AG

13:00

Lunch

14:00

End of Meeting

Main contact


Prof. Christos Reppas, National and Kapodistrian University of Athens

Professor in Pharmaceutics


Dr. Maria Vertzoni, National and Kapodistrian University of Athens

Associate Professor of Pharmaceutical technology and Biopharmaceutics

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