This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 955756.

Dr. Nicole Wyttenbach

F. Hoffmann – La Roche Ltd., Switzerland (Roche)

Senior Principal Scientist in pCMC Drug Delivery and Preformulation Sciences at Roche

Supervisor of ESR2 and ESR12


Dr. Nicole Wyttenbach is currently working at F. Hoffmann – La Roche Ltd. in Basel (Switzerland) as a Senior Principal Scientist in the field of drug delivery and preformulation sciences. She graduated as a pharmacist in 1995 at the University of Basel and obtained her PhD at the Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich (ETH Zürich) in 2000. Nicole Wyttenbach joined the preformulation group at Roche in 2000. Over the past 20 years, she specialized in pharmaceutical profiling and formulation of new chemical entities for oral delivery and developed new assays and strategies for physicochemical property determination in a variety of areas such as solubility, compatibility, solid-state forms or amorphous solid dispersions. She is author/co-author of several publications in peer reviewed journals, book chapters and patents.

Selected Publications

  • Wyttenbach, N., Alsenz, J., Grassmann, O., 2007. Miniaturized Assay for Solubility and Residual Solid Screening (SORESOS) in Early Drug Development. Pharm. Res. 24(5), 888-898.
  • Wyttenbach, N., Janas, C., Siam, M., Lauer, M.E., Jacob, L., Scheubel, E., Page, S., 2013. Miniaturized screening of polymers for amorphous drug stabilization (SPADS): Rapid assessment of solid dispersion systems. Eur. J. Pharm. Biopharm. 84(3), 583-598.
  • Saal, W., Ross, A., Wyttenbach, N., Alsenz, J., Kuentz, M., 2017. A systematic study of molecular interactions of anionic drugs with a dimethylaminoethyl methacrylate copolymer regarding solubility enhancement. Mol. Pharm. 14, 1243-1250.
  • Wyttenbach, N., Niederquell, A., Kuentz, M., 2020. Machine Estimation of Drug Melting Properties and Influence on Solubility Prediction. Mol. Pharm. 17(7), 2660-2671.