This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 955756.

Christoph Saal

Director SM Analytics Healthcare

Merck KGaA, Frankfurter Straße 250, 64293 Darmstadt, Germany

Supervisor of ESR8


Education: Study of Chemistry (Technical University Darmstadt), Habilitation in Pharmaceutical Technology (Goethe University Frankfurt)


  • Engineer for nuclear engineering at Siemens, Labhead and Director for Analytics Healthcare at Merck KGaA
  • Editor for European Journal of Pharmaceutical Sciences and Journal of Pharmaceutical Sciences
  • Expert in diverse expert groups at the European Directorate for the Quality of Medicines


Research Interest: Preformulation for New Chemical Entities, solid-state characterization, structural elucidation and impurity profiling including genotoxic impurities

Selected Publications

  • S. Paulekuhn, J. Dressman, C. Saal: „Trends in Active Pharmaceutical Ingredient Salt Selection based on Analysis of the Orange Book Database“, J. Med. Chem., 2007, 50(26), 6665-6672.

  • A. Petereit, C. Saal, “What is the Solubility of my Compound? Assessing Solubility for Pharmaceutical Research and Development Compounds” Am. Pharm. Rev., 2011, 14(5), 68-73.

  • C. Saal, A. Nair, (Editors), “Solubility in Pharmaceutical Chemistry”, De Gruyter, 2020, ISBN 978-3-11-05413-S

  • C. Schlesinger, L. Tapmeyer, S.D. Gumbert, M.U. Schmidt, C. Saal, „Absolute configuration of pharmaceutical research compounds by X-ray powder diffraction”, Angew. Chem. Int. Ed. 2018, doi:10.1002/anie.201713168

  • J. Schlingemann, C. Boucley, S. Hickert, L. Bourasseau, M. Walker, C. Celdran, T. Chemarin, C. Pegues, M. Fritzsche, J. Keitel, A. Goettsche, M. Seegel, S. Leicht, B. Guessregen, P. Reifenberg, S. Wetzel, T. Müller, F. Schooren, T. Schuster, M. Liebhold, A. Kirsch, P. Krueger, C. Saal, B. Mouton, S. Masanes, „Avoiding NDMA Formation in Metformin Pharmaceuticals“, Int. J. Pharm., 2022, 620, 121740,